1. 연구실:
경희대학교 약학대학 약학과
유기합성화학 및 화학생물학 연구실
2. P.I.: 김남중 (Nam-Jung Kim, Ph.D.)
3. 연락처: 손승환(02-961-0752, 010-3020-8008, thstmd1216@hanmail.net)
4. 기관 소개:
본 연구실은 organic chemistry tool을 기반으로 생체 내 신호 전달을 연구함과 동시에, 병리학적 이상 신호를 막을 수 있는 다양한 종류의 chemical construct를 개발하고 있습니다. 또한 이러한 기반 기술을 바탕으로 신규 의약품 후보물질의 개발을 시도하고 있습니다.
* 기타 의문사항에 대한 E-Mail, 방문 혹은 전화상담 모두 환영합니다.
5. 연구내용:
- Targeted drug delivery using small molecule-derived organic constructs
- Target identification of natural product based on chemoproteomics
- Medicinal chemistry based on rational design & natural products
- Organic synthesis & methodology
* Selected Papers :
Identification of actin as a direct proteomic target of berberine, using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly. ChemComm., 2017, in press.
An effective anti-viral approach targeting hepatitis B virus using NJK14047, a novel and selective biphenyl amide p38 MAPK inhibitor. Antimicrob. Agents Chemother., 2017, in press.
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. Bioorg. Med. Chem. Lett., 2017, 27, 2613-2616.
A novel p38 mitogen activated protein kinase (MAPK) specific inhibitor suppresses respiratory syncytial virus and influenza A virus replication by inhibiting virus-induced p38 MAPK activation. Biochem. Biophys. Res. Commun., 2016, 3, 311-316.
Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER independent mechanism. Bioorg. Med. Chem. Lett., 2016, 26, 1844-1848.
A versatile approach to flavones via one-pot Pd(II)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones. Org. Biomol. Chem., 2016, 14, 777-784.
Development of Small Molecule Cryptochrome Stabilizer as Modulators of the Circadian Clock. ChemMedChem, 2015, 10, 1489-1497.
Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate. Bioconjug, Chem., 2015, 26, 2216-2222.
Synthesis and biological evaluation of N-cyclopropylbenzamidie-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors. Bioorg. Med. Chem. Lett., 2015, 25, 3694-3698.
NJK14013, a novel synthetic estrogen receptor-alpha agonist, exhibits estrogen receptor-independent, tumor cell-specific cytotoxicity. Int. J. Oncol., 2015, 47, 280-286.
Identification and validation of cryptochrome inhibitors that modulate the molecular circadian clock. ACS. Chem. Biol., 2014, 9, 703-710.
6. 모집대상 및 근무 대우:
- 석사과정, 석박사 통합과정 지원자를 모집합니다. (석사과정 1명, 통합과정 1명)
- 석박사 통합과정 입학 가능자를 우선적으로 고려합니다.
- 등록금 및 생활비 지원합니다.
7. 제출서류: 이력서, 자기소개서, 학위증명서, 성적증명서
8. 대표논문실적
http://www.ncbi.nlm.nih.gov/pubmed/?term=nam-jung+kim